Despite all advances in surgical techniques there is still no adequate method for tracheal replacement, thus generating a scientific and technical challenge. In view of this and current tracheal anomaly treatments involves a high economic, social, and human cost, the present technology describes a method of producing tracheal tissue for transplantation, which is a functional respiratory tract with internal and external cell adhesion, and presents high efficiency.
The greatest benefit found in this technology is the high degree of decellularization, which allows implantation in vivo, with less immuno-mediated rejection and without the use of immunosuppressive, or in humans with small doses. In addition, mechanical, chemical, physical and biophotonic techniques are used for the removal of residual DNA, in order to obtain good frameworks with a reasonable cost that allows the exercise of translational medicine.
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