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UNESP
AUIN | Agência Unesp de Inovação
   

Tecnology

PHOSPHINIC COMPLEXES WITH ANTIMYCOBACTERIAL ACTIVITY

Carimbo Unesp

Low cost

Facilitates medical procedure

Functionality
New Materials
Human Health
PROBLEM

With the increase of resistant bacterias to the drugs used in the conventional treatment of tuberculosis, it is necessary to improve the activity of existing drugs or the development of new active drugs.

SOLUTION

The developed compounds proved to be effective in vitro against the main causative agent of Tuberculosis, Mycobacterium tuberculosis, sensitive to the current therapeutic regimen, as well as to the mono and Multi-drug-resistant clinical isolates.

The compounds developed have a high inhibitory activity against M. tuberculosis, as efficient or superior to the topical drugs currently used for treatment (rifampicin, isoniazid, ethambutol and pyrazinamide), with minimal cytotoxic effects in in vitro, culture macrophage cells. The big difference is also to act on the bacteria resistant to the current drugs. The use of the compounds would bring numerous benefits, such as:

  • Efficient treatment against tuberculosis and possible treatment against resistant tuberculosis;
  • Treatment time reduction;
  • With greater efficiency and less time, the new drug should reduce abandonment and treatment costs.

 


Idea

Laboratory

Prototype

Scheduling

Market
Agency Code
09NIT055
Patent
PI1001555-8

Agência Unesp de Inovação

Tel: +55 11 5627.0696

auin@unesp.br

https://auin.unesp.br

Date of deposit
06/05/2010
Inventor(s)

Clarice Queico Fujimura Leite

Fernando Rogério Pavan

Alzir Azevedo Batista

Gustavo Von Poelhsitz

Marilia Imaculada Frazão Barbosa

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